Product: Diquafosol (tetrasodium)
SNX15 Antibody Summary
| Immunogen |
Peptide with sequence C-EEILRLHLSQLPP corresponding to C-Terminus according to NP_037438.2, NP_680086.2.
|
| Specificity |
This antibody is expected to recognise both Human isoforms according to NP_037438.2 and NP_680086.2.
|
| Clonality |
Polyclonal
|
| Host |
Goat
|
| Gene |
SNX15
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||||
| Application Notes |
WB: Approx. 48 kDa band observed in human kidney lysates and in HEK293 lysates (calculated MW 38.2 kDa band according to NP_037438.2). Note: A single approx. 30-35 kDa band (probably representing the shorter isoform) was observed in human heart.
|
||||
| Positive Control |
|
||||
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for SNX15 Antibody
- clone iota unknown protein
- HSAF001435
- sorting nexin 15
- sorting nexin-15
Background
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
