SOCS-1 Antibody (4H1) Summary
| Immunogen |
Recombinant mouse SOCS-1 (2-78 a.a.)
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SOCS1
|
| Purity |
Protein A purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2) and 50% Glycerol
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for SOCS-1 Antibody (4H1)
- CIS1
- Cish1
- JAB
- JABTec-interacting protein 3
- JAK binding protein
- JAK-binding protein
- SOCS1
- SOCS-1
- SOCS-1CIS1
- SSI-1
- SSI-1CISH1
- SSI1cytokine-inducible SH2 protein 1
- STAT induced SH3 protein 1
- STAT-induced STAT inhibitor 1
- suppressor of cytokine signaling 1
- TIP3
- TIP-3
- TIP3Cish1
Background
The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the “SOCS box.” The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOC-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines. SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box. CIS (for cytokine-inducible SH2-containing protein) is also a member of the SOCS family.
