TLR7 Antibody Summary
| Immunogen |
Rabbit anti-TLR7 (IN) polyclonal antibody was raised against a peptide corresponding to 14 amino acids near the middle of mouse TLR7 (GenBank accession no. NP_573474).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TLR7
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This polyclonal antibody can be used for detection of TLR7 by Western blot at 0.5 to 2 ug/ml. It is human and mouse reactive.
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| Agonist |
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| Positive Control |
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Reactivity Notes
Human, Mouse
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
IgG purified
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Alternate Names for TLR7 Antibody
- TLR7
- toll-like receptor 7
Background
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome (6) and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus (7). Activation of TLR7 by VSV results in stimulation of the immune response including IFNalpha secretion, suggesting the importance of TLR7 in virus recognition.
