TOM1 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 450 and 492 of human target of myb1 using the numbering given in entry NP_005479.1 (GeneID 10043).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TOM1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS and 0.1% BSA
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TOM1 Antibody
- ADP-ribosylation factor-binding protein GGA3
- golgi associated, gamma adaptin ear containing, ARF binding protein 3
- golgi-associated, gamma adaptin ear containing, ARF binding protein 3
- KIAA0154Golgi-localized, gamma ear-containing, ARF-binding protein 3
Background
TOM1 (target of myb1) was originally identified as a gene activated by the expression of oncogenic Myb1. TOM1 has been shown to form a complex with tollip (toll-interacting protein) and to bind ubiquitin chains. It has also been shown to bind to clathrin heavy chain and is proposed to function to link polyubiquitinated proteins to clathrin and regulate endosomal trafficking of ubiquitinated proteins. Recent evidence shows that TOM1 bridges endofin to clathrin and is critical for the endosomal targeting of clathrin by endofin.
