TRAIL/TNFSF10 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human TRAIL. The exact sequence is proprietary.
|
| Localization |
Membrane; Single-pass type II membrane protein
|
| Predicted Species |
Monkey (97%), Primate (98%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TNFSF10
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Rhesus Monkey (97%), Chimpanzee (98%), Cat (81%), Pig (80%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TRAIL/TNFSF10 Antibody
- Apo-2 ligand
- APO2L
- Apo-2Ltumor necrosis factor (ligand) family, member 10
- APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
- CD253 antigen
- CD253
- Protein TRAIL
- TL2
- TNF-related apoptosis-inducing ligand
- TNFSF10
- TRAIL
- TRAILTNF-related apoptosis inducing ligand TRAIL
- tumor necrosis factor (ligand) superfamily, member 10
- tumor necrosis factor ligand superfamily member 10
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq]
