TRIM21/SSA1 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 425 and 475 of human Sjogren syndrome antigen A1 using the numbering given in entry NP_003132.2 (GeneID 6737).
|
| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TRIM21
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
54 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Human. Based on 100% sequence identity, this antibody is predicted to react with Rhesus Monkey, Gorilla, Chimpanzee, and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS and 0.1% BSA
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TRIM21/SSA1 Antibody
- 52 kDa ribonucleoprotein autoantigen Ro/SS-A
- 52 kDa Ro/SSA
- E3 ubiquitin-protein ligase TRIM21
- EC 6.3.2.-
- RNF81
- RNF81RING finger protein 81
- ro(SS-A)
- Ro52
- RO52SS-A
- Sicca syndrome antigen A
- Sjoegren syndrome type A antigen
- Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
- SSA1
- SSA1SSA
- TRIM21
- tripartite motif containing 21,52 kDa Ro protein
- tripartite motif-containing 21
- Tripartite motif-containing protein 21
Background
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
