TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody Summary
| Immunogen |
Synthetic peptide: GMSEACLHRKSHSERRSTLK, corresponding to amino acids 31-50 of Human Thyroid Hormone Receptor beta.
|
| Localization |
Nuclear
|
| Specificity |
Thyroid Hormone Receptor beta
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
THRB
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
Immunohistochemistry-Paraffin Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
|
||
| Positive Control |
|
Reactivity Notes
Cross-reacts with Human and Dog. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
10mM PBS (pH 7.4) and BSA
|
| Preservative |
Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody
- avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
- c-erbA-2
- c-erbA-beta
- ERBA2MGC126109
- ERBA-BETA
- GRTH
- MGC126110
- NR1A2
- NR1A2thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog 2)
- Nuclear receptor subfamily 1 group A member 2
- oncogene ERBA2
- PRTH
- THR1pituitary resistance to thyroid hormone
- THRB
- THRB1
- THRB2
- thyroid hormone receptor beta 1
- thyroid hormone receptor beta
- thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a)oncogene homolog 2, avian)
- TR beta 1
- v-ErbA2
Background
The Thyroid Hormone Receptor Beta protein is a nuclear hormone receptor for triiodothyronine. It has been shown to mediate the biological activities of, and is one of the several receptors for thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), which is characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
