Product: Chlorpromazine (D8 hydrochloride)
VEGF R2/KDR/Flk-1 Antibody Summary
| Immunogen |
Synthetic 15 amino acid peptide from internal region of human VEGFR2.
|
| Epitope |
internal domain of human
|
| Localization |
Type I membrane protein
|
| Marker |
Endothelial Cell Marker
|
| Specificity |
Human VEGFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SLC22A7 (60%).
|
| Predicted Species |
Bovine (93%), Bat (93%), Hamster (93%), Equine (93%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
KDR
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (93%), Mouse (87%), Rat (87%), Porcine (87%), Platypus (87%), Elephant (80%), Opossum (80%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
0.4 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for VEGF R2/KDR/Flk-1 Antibody
- CD309 antigen
- CD309
- EC 2.7.10
- EC 2.7.10.1
- Fetal liver kinase 1
- fetal liver kinase-1
- Flk1
- Flk-1
- FLK1tyrosine kinase growth factor receptor
- KDR
- kinase insert domain receptor (a type III receptor tyrosine kinase)
- Kinase insert domain receptor
- Protein-tyrosine kinase receptor flk-1
- soluble VEGFR2
- vascular endothelial growth factor receptor 2
- VEGF R2
- VEGFR
- VEGFR2
- VEGFR-2
Background
VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.
