Zyxin Antibody Summary
| Immunogen |
Peptide with sequence C-QQREKPRVQEKQH corresponding to internal region according to NP_003452.1.
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| Epitope |
internal region
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| Marker |
Focal Adhesion Marker
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| Specificity |
Reported variants represent identical protein: NP_003452.1, NP_001010972.1
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
ZYX
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 85 kDa band observed in human peripheral blood mononucleocytes lysates (calculated MW of 61.3 kDa band according to NP_003452.1). The observed molecular weight corresponds to earlier findings with different antibodies from other sources.
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Zyxin Antibody
- CTCL tumor antigen se14-3
- CTCL-associated antigen se14-3
- cutaneous T-cell lymphoma associated antigen se14-3
- Cutaneous T-cell lymphoma-associated antigen se14-3
- KIAA1125
- MGC31836
- predicted protein of HQ2893
- PRKCBP1
- PRO2893
- protein kinase C-binding protein 1
- Rack7
- RACK7protein kinase C binding protein 1
- zinc finger MYND domain containing protein 8
- Zinc finger MYND domain-containing protein 8
- zinc finger, MYND-type containing 8
- Zyx
- Zyxin 2
- Zyxin
Background
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
