c-Abl Antibody Summary
| Immunogen |
A synthetic peptide from the sequence adjacent to protein tyrosine kinasedomain of human c-Abl.
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| Localization |
Cytoplasmic and Nuclear
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| Specificity |
c-Abl
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ABL1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This product is useful for Immunohistochemistry Paraffin. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.
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| Positive Control |
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Reactivity Notes
Cross-reacts with Human and Mouse. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Prediluted antibody with PBS and BSA
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| Preservative |
0.1% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for c-Abl Antibody
- Abelson murine leukemia viral oncogene homolog 1
- ABL
- ABL1
- bcr/abl
- BCR-ABL1
- c-abl oncogene 1, non-receptor tyrosine kinase
- c-abl oncogene 1, receptor tyrosine kinase
- cAbl
- c-Abl
- EC 2.7.10
- EC 2.7.10.2
- JTK7
- JTK7bcr/abl
- p150bcr/c-abl oncogene protein
- Proto-oncogene c-Abl
- proto-oncogene tyrosine-protein kinase ABL1
- tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- v-abl
Background
The c Abl proto oncogene encodes a protein tyrosine kinase that is locatedin the cytoplasm and nucleus. In chronic myelogenous leukemia and in asubset of acute lymphoblastic leukemias, the c Abl proto oncogeneundergoes a (9;22) chromosomal translocation producing a novelrearranged chromosome (the Philadelphia chromosome) As the result of thefusion of c Abl sequences from chromosome 9 to the Bcr gene onchromosome 22. The molecular consequence of this translocation is thegeneration of a chimeric Bcr/Abl mRNA encoding activated Abl proteintyrosine kinase.
