Product: 1-Methyl-7-nitroisatoic anhydride
proBNP Antibody (5B6) Summary
| Immunogen |
Synthetic peptide: HPLGSPGSASDL, corresponding to N terminal amino acids 1-12 of Human proBNP.
|
| Localization |
Secreted
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| Specificity |
proBNP (5B6)
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| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
NPPB
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
In WB predicted molecular weight: 13 kDa. This product can be paired for ELISA with Mouse monoclonal [13G12] to proBNP, mouse monoclonal [11D1] tp proBNP, mouse monoclonal [10h4] tp proBNP, mouse monoclonal [5E2] to proBNP, mouse monoclonal [15F11] to proBNP and mouse monoclonal [24E11] to proBNP.
|
Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for proBNP Antibody (5B6)
- BNP
- brain type natriuretic peptide
- Gamma-brain natriuretic peptide
- natriuretic peptide B
- natriuretic peptide precursor B
- natriuretic peptides B
- natriuretic protein
Background
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa “signal” peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
