Product: Deoxycytidine triphosphate
eIF3e Antibody Summary
| Immunogen |
Peptide with sequence C-KLNQNSRSEAPN corresponding to C-Terminus according to NP_001559.1.
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| Epitope |
C-KLNQNSRSEAPN
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
EIF3E
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 50 kDa band observed in Daudi lysates (calculated MW of 52.2 kDa band according to NP_001559.1).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine, Bovine, Porcine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for eIF3e Antibody
- eIF-3 p48
- eIF3e
- eIF3-p48
- EIF3S6EIF3-P48
- Eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E
- eukaryotic translation initiation factor 3, subunit 6 (48kD)
- eukaryotic translation initiation factor 3, subunit 6 48kDa
- eukaryotic translation initiation factor 3, subunit E
- INT6eIF3-p46
- mammary tumor-associated protein INT6
- murine mammary tumor integration site 6 (oncogene homolog)
- Viral integration site protein INT-6 homolog
Background
Int6 is a candidate tumor suppressor in multiple neoplasms, and in particular, breast and lung cancers. The Int6 locus was initially identified as a common insertion site (CIS) in a genetic screen for transforming sequences in a breast cancer mouse model system. Insertion of mouse mammary tumor virus (MMTV) into this locus results in the production of an amino-terminal truncated gene product. Expression of the truncated Int6 product corresponds to cellular transformation in both in vivo and in vitro systems. This gene product plays a role in regulating translation initiation and is a component of the eIF3 translation initiation complex. There is evidence that suggests that Int6 may impart a negative role in the general translational machinery while promoting an increase in the expression of a subset of stressresponsive genes. Taken together, it is of great interest to further study the mechanism by which Int6 is involved in regulating cell growth.
