Product: L-Homocysteine thiolactone (hydrochloride)
PCBP1 Antibody Summary
| Immunogen |
Peptide with sequence C-ADLAKLNQVARQQSH corresponding to internal region according to CAA55016.1.
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| Epitope |
C-ADLAKLNQVARQQSH
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
PCBP1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 38 kDa band observed in lysates of HeLa and in human placenta lysates (calculated MW of 37.5 kDa band according to NP_006187.2).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PCBP1 Antibody
- alpha-CP1
- Heterogeneous nuclear ribonucleoprotein E1
- heterogenous nuclear ribonucleoprotein E1
- heterogenous nuclear ribonucleoprotein X
- hnRNP E1
- hnRNP-E1
- hnRNP-X
- HNRPE1
- HNRPX
- nucleic acid binding protein sub 2.3
- Nucleic acid-binding protein SUB2.3
- poly(rC) binding protein 1
- poly(rC)-binding protein 1
Background
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq]
