PERP Antibody Summary
| Immunogen |
Peptide with sequence CLPNYEDDLLGNAK corresponding to C-Terminus according to NP_071404.2.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
PERP
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 20 kDa band observed in human liver lysates (calculated MW of 21.4 kDa band according to NP_071404.2).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PERP Antibody
- dJ496H19.1
- KCP1KCP-1
- Keratinocyte-associated protein 1
- KRTCAP11110017A08Rik
- p53 apoptosis effector related to PMP22
- p53 apoptosis effector related to PMP-22
- P53-induced protein PIGPC1
- PERP, TP53 apoptosis effector
- PIGPC1RP3-496H19.1
- THWkeratinocytes associated protein 1
- Transmembrane protein THW
Background
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
