NFX1 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 250 and 300 of human Nuclear Transcription Factor, X-box Binding 1 using the numbering given in entry NP_002495.2 (GeneID 4799).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
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| Gene |
NFX1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for NFX1 Antibody
- DKFZp779G2416
- EC 6.3.2.-
- MGC20369
- NFX2transcriptional repressor NF-X1
- Nuclear transcription factor, X box-binding protein 1
- nuclear transcription factor, X-box binding 1
Background
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
