Elongin A Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 725 and the C-terminus (residue 772) of human Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, elongin A) using the numbering given in entry NP_003189.1 (GeneID 692
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TCEB3
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Elongin A Antibody
- EloA
- Elongin 110 kDa subunit
- elongin-A
- FLJ38760
- FLJ42849
- RNA polymerase II transcription factor SIII subunit A1
- SIII p110
- SIII
- TCEB3A
- transcription elongation factor B (SIII), polypeptide 3 (110kD, elongin A)
- transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
- transcription elongation factor B alpha subunit
- transcription elongation factor B polypeptide 3
Background
Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
