Cytochrome P450 1A2 Antibody Summary
| Immunogen |
Peptide with sequence C-HSENYKDNGGLIPEEK corresponding to internal region according to Uniprot Mouse NP_034123.1.
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| Specificity |
This antibody is not expected to cross-react to the similar P450 1A1.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CYP1A2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 60 kDa band observed in mouse fetal liver lysates (calculated MW of 58.2 kDa band according to NP_034123.1).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Rat.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Cytochrome P450 1A2 Antibody
- aryl hydrocarbon hydroxylase
- CP12
- CYPIA2
- Cytochrome P(3)450
- cytochrome P450 1A2
- Cytochrome P450 4
- cytochrome P450, family 1, subfamily A, polypeptide 2
- cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
- Cytochrome P450-P3
- dioxin-inducible P3-450
- EC 1.14.14.1
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- P3-450
- P450 form 4
- P450(PA)
- xenobiotic monooxygenase
Background
In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.
