Leptin R Antibody Summary
| Immunogen |
Peptide with sequence C-TQDDIEKHQSDAG corresponding to internal region according to NP_002294.2, NP_001003679.1, NP_001003680.1.
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| Specificity |
This antibody is expected to recognise all three reported isoforms (NP_002294.2; NP_001003679.1; NP_001003680.1).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
LEPR
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 150 kDa band observed in human brain lysates (calculated MW of 132 kDa band according to NP_002294.2).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Leptin R Antibody
- B219
- CD295 antigen
- CD295
- DB
- DKFZp686B1731
- huB219
- LEPR
- LEP-R
- Leptin R
- leptin receptor
- LeptinR
- OB R
- OB receptor
- OB-R
- OBRCD295
Background
Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.
