Product: Taurochenodeoxycholic acid
Cytochrome P450 1A1 Antibody Summary
| Immunogen |
Peptide with sequence C-QDRKLDENANVQLSD corresponding to internal region according to Uniprot Mouse NP_001129531.1.
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| Specificity |
This antibody is not expected to cross-react with the similar P450 1A2
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CYP1A1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 55 kDa band observed in rat lung lysates (calculated MW of 59.2 kDa band according to mouse NP_001129531.1 and 59.4 kDa band according to rat NP_036672.).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Cytochrome P450 1A1 Antibody
- AHH
- AHRR
- aryl hydrocarbon hydroxylase
- CP11
- CYP1
- CYPIA1
- cytochrome P1-450, dioxin-inducible
- cytochrome P450 1A1
- Cytochrome P450 form 6
- cytochrome P450, family 1, subfamily A, polypeptide 1
- Cytochrome P450-C
- Cytochrome P450-P1
- EC 1.14.14.1
- flavoprotein-linked monooxygenase
- P1-450
- P450-C
- P450DX
- subfamily I (aromatic compound-inducible), polypeptide 1
- xenobiotic monooxygenase
Background
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq]
