BRCA1 [p Ser1466] Antibody Summary
| Immunogen |
Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1466 according to the numbering given in entry NP_009225.1.
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| Modification |
p Ser1466
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
BRCA1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody can be used for Western Blot. *The investigator should determine the optimal dilution for a specific application.
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for BRCA1 [p Ser1466] Antibody
- BRCA1
- BRCAI
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein
- breast cancer 1, early onset
- breast cancer type 1 susceptibility protein
- EC 6.3.2
- EC 6.3.2.-
- IRIS
- PNCA4
- PSCP
- subunit 1
Background
BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer.
