Cadherin-11 Antibody Summary
| Immunogen |
Peptide with sequence C-ERRGHLRPSFHG corresponding to internal region according to NP_001788.2.
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| Epitope |
C-ERRGHLRPSFHG
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CDH11
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: In transfected HEK293 transiently expressing full-length human CDH11 (myc and DYKDDDDK tagged), a band of approx. 130 kDa band was observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-myc tag antibody.
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for Cadherin-11 Antibody
- CAD11OSF-4
- cadherin 11, type 2, OB-cadherin (osteoblast)
- Cadherin11
- Cadherin-11
- CDH11
- CDHOB
- OB
- OB-Cadherin
- Osteoblast cadherin
Background
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
