NEIL1 Antibody Summary
| Immunogen |
Recombinant full-length human NEIL1 protein
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| Localization |
Nuclear
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| Specificity |
NEIL1
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NEIL1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: 1/1000. Predicted molecular weight: 44 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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| Positive Control |
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| Publications |
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Reactivity Notes
Cross-reacts with Human. Rat reactivity reported in scientific literature (PMID: 25172893) Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS and 20% Glycerol
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Alternate Names for NEIL1 Antibody
- DNA-(apurinic or apyrimidinic site) lyase Neil1
- EC 3.2.2.-
- EC 4.2.99.18
- endonuclease 8-like 1
- endonuclease VIII
- Endonuclease VIII-like 1
- FLJ22402
- FPG1DNA glycosylase/AP lyase Neil1
- hFPG1
- NEH1
- nei endonuclease VIII-like 1 (E. coli)
- Nei homolog 1
- NEI1
- Nei-like protein 1
Background
Prokaryotes and lower eukaryotes possess activities that remove the plethora of oxidative DNA base damages produced during normal oxidative metabolism and which have been associated with cancer and aging. The availability of the human genome sequence has precipitated identification of human homologs of Escherichia coli Nei. Human NEIL1 is a DNA glycosylase, that phylogenetically belongs to the Fpg/Nei family, primarily found in the bacterial kingdom and is functionally homologous to bacterial Nei. Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylases. The NEIL1 gene is located on the long arm of chromosome 15 that is frequently deleted in human cancers.
