Product: ZM39925 (hydrochloride)
Sarcalumenin Antibody (XIIC4) Summary
| Immunogen |
Purified rabbit sarcoplasmic reticulum membrane vesicles.
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| Specificity |
This specifically detects sarcalumenin and the 53 kDa glycoprotein splice variant.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
SRL
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Detects an approx. 53 kDa and a 160 kDa protein representing the glycoprotein and sarcalumenin respectively, in rabbit skeletal muscle extracts. IF: Staining of sarcalumenin and its splice variant in rabbit skeletal muscle results in staining that co-localizes with calcium ATPase in the longitudinal sarcoplasmic reticulum (SR) and the terminal cisternae.
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
Ascites with PBS
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| Preservative |
0.05% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Protein A purified
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Alternate Names for Sarcalumenin Antibody (XIIC4)
- sarcalumenin
Background
Sarcalumenin is a 160 kDa acidic calcium binding glycoprotein found to reside at the inner membrane of the sarcoplasmic reticulum in a calcium dependent manner.The gene encoding sarcalumenin also encodes an alternate splice variant, a 53 kDa glycoprotein which co-localizes with sarcalumenin. These two proteins are found in the longitudinal sarcoplasmic reticulum and the nonjunctional membranes of the terminal cisternae. They have been observed to co-localize with calcium-ATPase suggesting that they are involved in calcium transport and sequestration.
