DEDD2 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to residues 144-129 of the DEDD2 protein.
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| Specificity |
DEDD2
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DEDD2
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| Purity |
Unpurified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful for Western Blot.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
36.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Positive Control |
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Reactivity Notes
This antibody is reactive against Human
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Whole antisera
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| Preservative |
0.02% Sodium Azide
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| Purity |
Unpurified
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Alternate Names for DEDD2 Antibody
- death effector domain containing 2
- death effector domain-containing DNA binding protein 2
- DED-containing protein FLAME-3
- DNA-binding death effector domain-containing protein 2
- FADD-like apoptotic molecule 3
- FLAME3
- FLAME-3
Background
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
