Insulin Antibody (3A6) Summary
| Immunogen |
purified human insulin.
|
| Specificity |
Insulin. This cross-reacts with human proinsulin, bovine insulin (30%) and porcine insulin. No cross-reaction with free C-peptide.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
INS
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Detection of insulin in two-site enzyme immunoassay. Following pairs are recommended (capture-detection): NB100-73008 – href=”http://www.novusbio.com/Insulin-Antibody-8E2_NB100-73009.html” target=”_blank”>NB100-73009. Use in ELISA reported in scientific literature (PMID 28132934).
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| Publications |
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Reactivity Notes
Mouse reactivity reported in scientific literature (PMID: 28132934).
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Insulin Antibody (3A6)
- IDDM2
- ILPR
- INS
- Insulin
- IRDN
- MODY10
- proinsulin
Background
Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
