PPAPDC1B/DPPL1 Antibody Summary
Immunogen |
Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human PPAPDC1B. The immunogen is located within amino acids 30 – 80 of PPAPDC1B.
|
Clonality |
Polyclonal
|
Host |
Rabbit
|
Gene |
PPAPDC1B
|
Purity |
Immunogen affinity purified
|
Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
Dilutions |
|
||
Control Peptide |
|
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
Buffer |
PBS
|
Preservative |
0.02% Sodium Azide
|
Concentration |
1 mg/ml
|
Purity |
Immunogen affinity purified
|
Alternate Names for PPAPDC1B/DPPL1 Antibody
- diacylglycerol pyrophosphate like 1
- DPPL1
- EC 3.1.3.4
- HTPAPphosphatidate phosphatase PPAPDC1B
- phosphatidic acid phosphatase type 2 domain containing 1B
- Phosphatidic acid phosphatase type 2 domain-containing protein 1B
Background
Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.