Fibulin-3/EFEMP1 Antibody Summary
| Immunogen |
Synthetic peptide (N-term): TYTQCTDGYEWDPVRQQC.
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| Localization |
Secreted
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| Specificity |
The Anti EFEMP1 selective was generated against a conserved sequence near the N terminal region that is unique to EFEMP1 protein only. This detects a strong 62 kDa EFEMP1 protein in human.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
EFEMP1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IP: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Detects a band of approximately 62 kDa (predicted molecular weight: 60 kDa). Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
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| Positive Control |
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Reactivity Notes
Cross-reacts with Human and Rat. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Tris/Glycine buffer pH 7.5-7.9, stabilizing protein, and glycerol
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for Fibulin-3/EFEMP1 Antibody
- DHRD
- EFEMP1
- EGF containing fibulin-like extracellular matrix protein 1
- EGF-containing fibulin-like extracellular matrix protein 1
- Extracellular protein S1-5
- FBLN3
- FBLN3DRAD
- FBNLFLJ35535
- FIBL-3
- Fibrillin-like protein
- fibrillin-like
- Fibulin 3
- fibulin-3
- MGC111353
- MLVT
- MTLV
- S1-5
Background
This gene spans approximately 18 kb of genomic DNA and consists of 12 exons. Two transcripts with distinct 5 UTR have been described; the resulting proteins have distinct N-terminal amino acid sequences. Translation initiation from internal methionine residues was observed with in vitro translation. A signal peptide sequence is predicted for translation initiation sites 1, 2, and 4. The protein isoforms contain 5 or 6 calcium-binding EGF2 domains and 5 or 6 EGF2 domains. Mutations in this gene cause the retinal disease Malattia Leventinese.
