beta-Synuclein Antibody Summary
| Immunogen |
Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).
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| Localization |
Cytoplasmic
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| Specificity |
This is specific for beta synuclein and does not cross react withalpha or gamma synuclein.Stains neuronal cytosol and presynaptic terminals.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
SNCB
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IHC-P: Ready to use for 10 minutes at room temperature. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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| Positive Control |
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Reactivity Notes
Cross-reacts with Human and Rat.Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS and BSA
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| Preservative |
Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for beta-Synuclein Antibody
- beta-Synuclein
- SNCB
- synuclein, beta
- Synuclein-beta
Background
Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha synuclein, beta synuclein, and gamma synuclein. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. Beta synuclein protein is found in Alzheimer disease neurofibrillary lesions. The sequence of beta synuclein is 61% identical to alpha synuclein, which is also present in these lesions.Beta synuclein is an acidic protein and extremely heat-resistant. It has a chaperone-like activity and has been suggested to inhibit alpha synuclein aggregation.
