Product: Iproniazid (phosphate)
Syntaxin 1A Antibody (SP6) Summary
| Immunogen |
Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human Synaptophysin mAb antibodies
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| Specificity |
Syntaxin (SP6)
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| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
STX1A
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Mouse, Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for Syntaxin 1A Antibody (SP6)
- Brain Syntaxin
- HPC-1
- Neuron-specific antigen HPC-1
- p35-1
- STX1A
- STX1P35-1
- SYN1A
- syntaxin 1A (brain)
- Syntaxin 1A
- syntaxin-1A
Background
Syntaxin 1, also known as HPC1, is a 35 kDa integral membrane protein, which along with SNAP25 and VAMP/synaptobrevin plays a role in vesicular trafficking and membrane fusion. Two Syntaxin 1 isoforms have been identified, Syntaxin 1A which is localized to nerve terminals of sensory neurons and nerve fibers reaching small blood vessels, and Syntaxin 1B which is localized to motor end plates and muscle spindles. The SNARE (soluble N-ethylmaleimide sensitive fusion protein [NSF] attachment protein [SNAPs] receptors) hypothesis of membrane fusion proposes that Syntaxin 1A and SNAP25 (target membrane SNAREs, t-SNAREs) and VAMP/synaptobrevin (vesicular SNAREs, vSNAREs) bind together to form a tripartite structure that along with soluble cytosolic proteins allows for close membrane apposition of donor and target membranes thereby facilitating membrane fusion. The interaction of Syntaxin 1A with vSNAREs is thought to be negatively regulated by the binding of Munc18 to Syntaxin 1A and this interaction is controlled by Cdk5 phosphorylation of Munc18. Syntaxin 1A can be phosphorylated by casein kinase II and phosphorylation of Syntaxin enhances its interaction with Synaptotagmin.
