mGluR6 Antibody Summary
| Immunogen |
Synthetic 12 amino acid peptide from N-terminal extracellular domain of human GRM6 / MGLUR6.
|
| Specificity |
Human GRM6 / MGLUR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
GRM6
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Chimpanzee, Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Rat (83%), Canine (83%), Panda (83%), Rabbit (83%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for mGluR6 Antibody
- CSNB1B
- glutamate receptor, metabotropic 6
- Gm3
- GPRC1F
- GPRC1Fmetabotropic glutamate receptor 6
- GRM6
- mGlu6
- mGluR6
- MGLUR6DKFZp686H1993
Background
Metabotropic Glutamate Receptor GRM6 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and Group III receptors are linked to the inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities.
