Product: D-alpha-Hydroxyglutaric acid (disodium salt)
Cortactin Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Cortactin. The exact sequence is proprietary.
|
| Localization |
Cytoplasm; cytoskeleton (By similarity); Cell projection; lamellipodium (By similarity); ruffle (By similarity)
|
| Predicted Species |
Rhesus Macaque (95%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CTTN
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
62 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (80%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Cortactin Antibody
- 1110020L01Rik
- Amplaxin
- Cortactin
- CTTN
- ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 srcsubstrate)
- EMS1
- EMS1amplaxin
- FLJ34459
- Oncogene EMS1
- src substrate cortactin
Background
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq]
