RUVBL1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human RUVBL1. The exact sequence is proprietary.
|
| Localization |
Nucleus matrix; Nucleus; nucleoplasm; Cytoplasm; Membrane
|
| Predicted Species |
Mouse (99%), Rat (99%), Primate (100%), Xenopus (95%), Monkey (100%), Chicken (95%), Bovine (98%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
RUVBL1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Rhesus Monkey (100%), Chimpanzee (100%), Xenopus laevis (95%), Zebrafish (88%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.64 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for RUVBL1 Antibody
- 49 kDa TATA box-binding protein-interacting protein
- 54 kDa erythrocyte cytosolic protein
- EC 3.6.1
- EC 3.6.4.12,49 kDa TBP-interacting protein
- ECP54
- INO80 complex subunit H
- INO80HTIP49A
- NMP 238
- NMP238ECP-54
- Nuclear matrix protein 238
- Pontin 52
- PONTIN
- Pontin52
- RuvB (E coli homolog)-like 1
- RuvB-like 1 (E. coli)
- ruvB-like 1
- RVB1
- TATA binding protein interacting protein 49 kDa
- TIH1
- TIP49a
- TIP49TAP54-alpha
- TIP60-associated protein 54-alpha
Background
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3 to 5) activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
