4-1BB Ligand/TNFSF9 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human TNFSF9. The exact sequence is proprietary.
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| Localization |
Membrane; Single-pass type II membrane protein
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| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
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| Gene |
TNFSF9
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for 4-1BB Ligand/TNFSF9 Antibody
- 41BB Ligand
- 4-1BB Ligand
- 4-1BBL
- 4-1BB-L
- CD137L
- homolog of mouse 4-1BB-L
- receptor 4-1BB ligand
- TNFSF9
- tumor necrosis factor (ligand) superfamily, member 9
- tumor necrosis factor ligand superfamily member 9
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
