KRIT1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human KRIT1. The exact sequence is proprietary.
|
| Localization |
Membrane; Peripheral membrane protein
|
| Predicted Species |
Mouse (94%), Rat (95%), Rhesus Macaque (99%), Chicken (93%), Bovine (98%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
KRIT1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Zebrafish (82%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.74 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for KRIT1 Antibody
- CAMcerebral cavernous malformations 1
- CCM1ankyrin repeat-containing protein Krit1
- Cerebral cavernous malformations 1 protein
- Krev interaction trapped 1
- krev interaction trapped protein 1
- KRIT1, ankyrin repeat containing
Background
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
