Chitotriosidase/CHIT1 Antibody (1D9G2) Summary
| Immunogen |
Purified recombinant fragment of CHIT1(aa22-137) expressed in E. Coli.
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| Specificity |
Specific for CHIT1.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CHIT1
|
| Purity |
Unpurified
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Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
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Alternate Names for Chitotriosidase/CHIT1 Antibody (1D9G2)
- CHI3
- CHIT1
- CHITCHI3
- chitinase 1 (chitotriosidase)
- chitinase-1
- Chitotriosidase
- chitotriosidase-1
- EC 3.2.1.14
- FLJ00314
- MGC125322
- plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
Background
Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.
