CDC25C Antibody (1F12) Summary
| Immunogen |
Purified recombinant fragment of human CDC25C expressed in E. Coli.
|
| Marker |
Mitosis Marker
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CDC25C
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for CDC25C Antibody (1F12)
- CDC 25
- CDC25
- CDC25C
- cell division cycle 25 homolog C (S. cerevisiae)
- cell division cycle 25 homolog C (S. pombe)
- cell division cycle 25C
- Dual specificity phosphatase Cdc25C
- EC 3.1.3.48
- mitosis inducer CDC25
- M-phase inducer phosphatase 3
- phosphotyrosine phosphatase
Background
Cdc25C is a tyrosine protein phosphatase required for progression of the cell cycle. Cdc25C activates cell cycle-specific cyclin-dependent kinases (CDKs), including cdc2, via dephosphorylation events (1,2). Cdc25C is activated via phosphorylation at Ser216 (3). In response to DNA damage and DNA replicational stress, Chk1 and Chk2 phosphorylate Cdc25C to prevent entry into mitosis (4,5).
