5-Nucleotidase/CD73 Antibody (1D7) Summary
| Immunogen |
Purified recombinant fragment of NT5E expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
NT5E
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for 5-Nucleotidase/CD73 Antibody (1D7)
- 5 nucleotidase (CD73)
- 5-NT
- 5-NT
- 5Nucleotidase
- 5-Nucleotidase
- 5-nucleotidase, ecto (CD73)
- CD73 antigen
- CD73
- E5NT
- EC 3.1.3.5
- ecto-5-nucleotidase
- eN
- eNT
- NT
- NT55-nucleotidase
- NT5E
- NTE
- Purine 5-Prime-Nucleotidase
Background
Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]
