Brk Antibody (2H12B8) Summary
| Immunogen |
Ni-NTA purified truncated recombinant PTK6 expressed in E. Coli strain BL21 (DE3).
|
| Specificity |
PTK6 (2H12B8)
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PTK6
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Brk Antibody (2H12B8)
- Breast tumor kinase
- Brk
- BRKprotein-tyrosine kinase 6
- EC 2.7.10
- EC 2.7.10.2
- FLJ42088
- protein-tyrosine kinase BRK
- PTK6 protein tyrosine kinase 6
- PTK6
- Sik
- Tksk
- Tyrosine-protein kinase BRK
Background
PTK6 (protein tyrosine kinase 6, BRK or FLJ42088),with 451-amino acid protein (about 51kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Over expression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.
