TCF-3/E2A Antibody (6B8) Summary
| Immunogen |
Purified recombinant fragment of human TCF3 expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
TCF3
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for TCF-3/E2A Antibody (6B8)
- bHLHb21
- bHLHb21TCF-3
- Class B basic helix-loop-helix protein 21
- E2A immunoglobulin enhancer-binding factor E12/E47
- E2A
- E2AKappa-E2-binding factor
- Immunoglobulin enhancer-binding factor E12/E47
- Immunoglobulin transcription factor 1
- ITF1
- ITF1Transcription factor ITF-1
- Kappa-E2-binding factor
- MGC129647
- MGC129648
- Pan2
- TCF-3
- Tcfe2a
- transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- Transcription factor 3
- transcription factor E2-alpha
- VDIR
- VDR interacting repressor
Background
T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.
