Serum Amyloid A1 Antibody (SAA1) Summary
| Immunogen |
human recombinant SAA, conjugated with carrier protein.
|
| Specificity |
Human recombinant SAA
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SAA1
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Recommended pairs for sandwich immunoassay (coating – conjugate): NB100-73071 (Coating) – NB100-73077 (Conjugate), NB100-73077 (Coating) – NB100-73071 (Conjugate), NB100-73072 (Coating) – NB100-73071 (Conjugate), NB100-73071 (Coating) – NB100-73072 (Conjugate)
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Serum Amyloid A1 Antibody (SAA1)
- MGC111216
- PIG4
- SAA
- SAA1
- SAA2
- serum amyloid A protein
- Serum Amyloid A1
- TP53I4
- tumor protein p53 inducible protein 4
Background
The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAAs (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDLs to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a “housekeeping” role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis.
