Recombinant Human Stathmin 1 Protein Summary
| Description |
A recombinant protein with a His-tag corresponding to amino acids 1 to 149 of Human Stathmin 1
Source: E. coli Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD |
| Preparation Method |
E.coli
|
| Protein/Peptide Type |
Recombinant Protein
|
| Gene |
STMN1
|
| Purity |
>95% pure by SDS-PAGE
|
Applications/Dilutions
| Theoretical MW |
19.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
| Purity |
>95% pure by SDS-PAGE
|
Notes
The purity of this protein is > 95% by SDS-PAGE. Molecular weight is 19.4 kDa (169aa), confirmed by MALDI-TOF.
Alternate Names for Recombinant Human Stathmin 1 Protein
- C1orf215
- chromosome 1 open reading frame 215
- Lag
- Leukemia-associated phosphoprotein p18
- metablastin
- MGC138869
- Oncoprotein 18
- Op18
- OP18MGC138870
- phosphoprotein 19
- Phosphoprotein p19
- PP17
- PP19
- PR22
- prosolin
- Protein Pr22
- SMNLAP18FLJ32206
- stathmin 1
- stathmin 1/oncoprotein 18
- stathmin
- transmembrane protein C1orf215
Background
Stathmin is a ubiquitous phosphoprotein proposed to play a general role as an intracellular relay integrating diverse regulatory signals of the cellular environment. Also, Stathmin protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. The role of Stathmin in regulation of the cell cycle causes it to be an oncoprotein (Oncoprotein 18, op18). When Stathmin is mutated and not functioning properly, this protein can cause uncontrolled cell proliferation. Recombinant human Stathmin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
