Product: 3,6-Dichlorotrimellitic acid
Pin1 Antibody (3G8) Summary
| Immunogen |
Recombinant human Pin1 (1-163 aa) purified from E. coli
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| Specificity |
Anti-human Pin1 mAb, clone 3G8, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Pin1 protein.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
PIN1
|
| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4) and 10% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
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Alternate Names for Pin1 Antibody (3G8)
- dod
- EC 5.2.1.8
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1
- peptidyl-prolyl cis/trans isomerase, NIMA-interacting
- peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- Peptidyl-prolyl cis-trans isomerase Pin1
- Pin1
- PPIase Pin1
- prolyl isomerase
- protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
- protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
- Rotamase Pin1
- UBL5
Background
Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
