Product: Niclosamide (monohydrate)
Uev1a/UBE2V1 Antibody Summary
| Immunogen |
Antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A. The immunogen is located within the last 50 amino acids of UEV1A.
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| Specificity |
Anti-UEV1A may also recognize other isoforms of UEV1A.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
UBE2V1
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| Purity |
Ion exchange chromatography
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Applications/Dilutions
| Dilutions |
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| Application Notes |
UEV1A antibody can be used for detection of UEV1A by Western blot at 1 to 2 mg/ml. Anti-UEV1A may also recognize other isoforms of UEV1A.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Ion exchange chromatography
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Alternate Names for Uev1a/UBE2V1 Antibody
- CIR1
- CROC1
- CROC1TRAF6-regulated IKK activator 1 beta Uev1A
- CROC-1UBE2V
- UBE2V1
- ubiquitin-conjugating enzyme E2 variant 1
- Uev1a
- UEV-1CIR1
- UEV1DNA-binding protein
Background
Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.
