D4-GDI/RhoGDI2 Antibody Summary
| Immunogen |
Recombinant full-length human D4-GDI/RhoGDI2 protein.
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| Specificity |
This product is specific for D4-GDI/RhoGDI2.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ARHGDIB
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
This product is specific for Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
10mM PBS (pH 7.4)
|
| Preservative |
Sodium Azide
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| Purity |
Immunogen affinity purified
|
Alternate Names for D4-GDI/RhoGDI2 Antibody
- ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
- D4
- GDIA2
- GDID4
- LYGDI
- Ly-GDI
- RAP1GN1
- RhoGDI2
Background
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
